Guillain barre syndrome and its association with covid-19 infection – A clinical case series

Original Article

Author Details : Madhavi Karri*, Deepak Jacob, Balakrishnan Ramasamy, Santhosh Perumal

Volume : 7, Issue : 4, Year : 2021

Article Page : 326-333

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Background: A novel coronavirus (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2). This pandemic has been globally alarming in the current period. Several neurological manifestations are reported occurring with the infection. Guillain barre syndrome (GBS) or acute onset inflammatory polyradiculoneuropathy has been among the frequent manifestations observed among them.
Objectives: To know the pattern and outcome of GBS in COVID-19 affected individuals.
Methods and Methods: We have taken six individuals admitted with flaccid quadriparesis in the last two months. All were affected recently by COVID 19 infection, which RT PCR of the nasopharyngeal swab confirmed. The study participants have undergone nerve conduction studies and have been diagnosed with Guillain Barre syndrome using Brighton criteria. We did cerebrospinal fluid (CSF) analysis after admission. We initiated all patients on Intravenous immunoglobulin according to body weight (2g/kg divided over five days). We used the Barthel index score to assess the outcome of the individuals.
Results: We observed a mean duration of 18.25 days between the COVID-19 infection and the onset of symptoms. Apart from motor quadriparesis and sensory symptoms being in common, we also noticed cranial nerves and autonomic involvement. We made the diagnosis using the nerve conduction studies and Brighton criteria. After initiating intravenous immunoglobulin, all patients had a good outcome, and quality of life was better after two months of follow up.
Conclusion: Guillain Barre syndrome is one of the neurological manifestations of COVID-19 and has a dramatic response with intravenous immunoglobulin and better outcome with treatment.

Keywords: Guillain Barre syndrome, COVID19 infection, Intravenous immunoglobulin, Barthel index

How to cite : Karri M, Jacob D, Ramasamy B, Perumal S, Guillain barre syndrome and its association with covid-19 infection – A clinical case series. IP Indian J Neurosci 2021;7(4):326-333

Copyright © 2021 by author(s) and IP Indian J Neurosci. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 26-11-2021

Accepted : 03-12-2021

Available online : 05-01-2022

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