Serum uric acid as biomarker for mania: An exploratory prospective study

Original Article

Author Details : Ambu Pandey*, Kamal Narayan Kalita, Aprajeeta Baruah

Volume : 7, Issue : 4, Year : 2021

Article Page : 311-314

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Bipolar Disorder is a major mental illness characterized by episodic occurrence of mood symptoms which can be of mania, depression or a mixed episode. The role of Uric Acid in the etiopathogenesis of episodic mental illnesses might be considered recognized long back in 19th century. Lithium was used as treatment for gouty arthritis and that in some cases helped to control mental illnesses. Multiple role of uric acid in the Central Nervous System have been recognized now. In the present study 30 patients in manic episodes were included and their serum Uric Acid level was compared to age and sex matched healthy controls twice at the interval of three weeks. It was found that Uric Acid level of cases was significantly higher than in controls before the initiation of treatment. Uric Acid level of manic group showed a significant decline after three weeks of treatment initiation. There was no significant change in Uric Acid level of control group after three weeks
Conclusion: Serum Uric Acid levels are elevated during manic phase of Bipolar Disorder and decreases after initiation of treatment. There may be more research to find whether uric acid can be considered a biomarker for Bipolar illnesses and also an indicator for treatment response.
Keywords: Uric acid, Mania, Bipolar illness, Biomarker

How to cite : Pandey A, Kalita K N, Baruah A, Serum uric acid as biomarker for mania: An exploratory prospective study. IP Indian J Neurosci 2021;7(4):311-314

Copyright © 2021 by author(s) and IP Indian J Neurosci. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 17-11-2021

Accepted : 23-11-2021

Available online : 05-01-2022

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