GABA: A critical player for regulating synaptic plasticity and adult neurogenesis

Review Article

Author Details : Mamata Mishra*, Pankaj Seth

Volume : 7, Issue : 4, Year : 2021

Article Page : 275-280

Suggest article by email


Background: During aging, the decrease of cognitive ability is believed to be the cause of age related neuronal damage and reduced proliferation and differentiation of adult-born neural precursor cells. To modulate the synaptic plasticity and adult neurogenesis, it is of immense importance to enhance the potential of resident neural stem cells of hippocampus and sub ventricular zone (SVZ). The necessity to restore brain functions is enormous in the neurodegenerative disease like Alzheimer, Parkinson diseases, stress induced cognitive dysfunction, depression and age-associated and HIV-associated dementia. As a pioneer transmitter, Gamma Amino Butaric Acid (GABA) influences the activity dependent adult neurogenesis and excites immature neurons in adult hippocampus. GABA holds the key for making adult immature neuron to mature functional neuron hence plays critical role in adult neurogenesis.
Summary: This review aims to discuss about the spatio-temporal expression of various subunit of GABA-A receptor and how these subunits intimately modulates the synaptic plasticity.
Key messages: During developmental period GABAergic neurons mature at early stages and regulate overall neural activity much before the activity of glutamate. Not only during development but also during adult neurogenesis GABA plays a significant role in neurite outgrowth and establishing well network.

Keywords: Adult neurogenesis, GABA, Synaptic plasticity, Dentate gyrus, hippocampus, Subventricular zone (SVZ)

How to cite : Mishra M, Seth P, GABA: A critical player for regulating synaptic plasticity and adult neurogenesis. IP Indian J Neurosci 2021;7(4):275-280

Copyright © 2021 by author(s) and IP Indian J Neurosci. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 19-10-2021

Accepted : 09-11-2021

Available online : 05-01-2022

View Article

PDF File   Full Text Article

Copyright permission

Get article permission for commercial use


PDF File   XML File   ePub File

Digital Object Identifier (DOI)

Article DOI

Article Metrics

Article Access statistics

Viewed: 66

PDF Downloaded: 33

Open Abstract (Increase article citation) Wiki in hindi